The Role of Complement in Cancer Immunotherapy

• Other Authors: Taylor, Ronald P. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; complement; therapeutic monoclonal antibodies (mAbs); Ca2+; fluorescence microscopy; gC1qR; breast cancer; xenotransplant model; complement system; cancer; immune infiltrate; tumor microenvironment; tumor growth; anaphylatoxins; antibody dependent cellular cytotoxicity; phagocytosis; complement receptors; CD46; membrane cofactor protein (MCP); cancer therapeutics; measles virus; adenovirus; antibody-drug conjugates; immunity; myeloid cells; therapeutics; antibody therapy; cluster of differentiation 19 (CD19); CD19; Fc fragment crystallizable (Fc); Fc engineering; complement-dependent cytotoxicity (CDC); antibody-dependent cell-mediated cytotoxicity (ADCC); angiogenesis; ocular pathology; cytotoxicity; monoclonal antibody; B-cell lymphoma; chronic lymphocytic leukemia (CLL); complement C5a; complement C3a; mammary carcinoma; immunoregulation; tumor infiltrating leukocytes; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the killing of malignant cells. Indeed, there are now n...