Advances and Novel Treatment Options in Metastatic Melanoma

• Other Authors: Facchiano, Antonio (Editor), Del Bufalo, Donatella (Editor), Carè, Alessandra (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; melanoma; invasion; WNT5A; MARCKS; phosphorylation; MANS peptide; nanoparticles; cell therapy; tumor microenvironment; sex/gender; sex-hormones; immunity; microRNAs; immunotherapy; BRAF-mutant melanoma; BRAF inhibitor; mechanism of action; targeted therapy; tumour microenvironment; plasmacytoid dendritic cells; lactate dehydrogenase; TLR; interferon; CXCL10; TPC2; HIPPO; SOCE; metastasis; essential oils; angiogenesis; apoptosis; uveal melanoma (UM); metastatic uveal melanoma (mUM); prognostication; adjuvant therapy; metastatic therapy; metastatic dormancy; liver-directed-therapies; targeted-therapy; combined therapy; protein tyrosine phosphatase; PTPs inhibitors; melanoma immune infiltrate; BRAF inhibitors; microenvironment; resistance; therapy; therapeutic resistance; exosomes; extracellular vesicles; diagnosis; prognosis; ctDNA; liquid biopsy; prediction; patient stratification; BRAF; arthralgia; rheumatoid arthritis; carbonic anhydrase; hedgehog; cyclopamine; small molecules; acetazolamide; motility; metalloproteinases; FAK; cancer; mucosal melanoma; nivolumab; pembrolizumab; ipilimumab; radiotherapy; cholinergic system; acetylcholine; muscarinic receptors; nicotinic receptors; melanoma metastasis; ShcD adaptor protein; amoeboid motility; Rac1; DOCK4; melanoma PDX; target therapy; cancer stem cells; slow cycling phenotype; drug resistance; OXPHOS; lipid metabolism; cancer associated fibroblast; melanomagenesis; biomarkers; checkpoint inhibitor; PD-1; melanoma markers; cytokines; machine learning; Support Vector Machine; principal component analysis; BCL2L10; STAT3; cytotoxicity; survival; ABT-737; Bcl-2 family; ML258; HuR; MITF; metastases; siRNA; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The book presents several studies reporting advances on melanoma pathogenesis, diagnosis and therapy. It represents a milestone on the state of the art, updated at 2021, and also presents the current knowledge on the future developments in melanoma field.