ABC Transporters in Human Diseases

• Other Authors: Falguières, Thomas (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; ABC transporters; drug action; regulatory extension; regulatory insertion; mechanism of action; MRP1; MRP4; breast cancer; proliferation; migration; invasion; cAMP; ABCG2; ABCB1; blood-brain barrier; PET; Alzheimer's disease; beta-amyloid; tariquidar; erlotinib; ABCG5; ABCG8; ATP-binding cassette transporter; cholesterol; polar relay; sitosterolemia; 5' untranslated region; cis-acting elements; ABCA subfamily; bioinformatics; ABC transporter; therapy response; disease-free survival; next-generation sequencing; competitive allele-specific PCR; P-glycoprotein; amyloid-beta; neuron; SK-N-SH; gene therapy; AAV; PFIC; BSEP; ABCB11; bile salts; intrahepatic cholestasis; chaperones; PFIC2; BRIC; ATP-binding cassette transporter A1 (ABCA1); cholesterol homeostasis; reverse cholesterol transport; HDL-C; dyslipidemia; type 2 diabetes; microparticles; ABCG2 genotype; clinico-genetic analysis; ethnic specificity; genetic variations; precision medicine; rare variant; Roma; serum uric acid; SUA-lowering therapy; urate transporter; bile secretion; ABCB4; ABCC2; ABCG5/G8; molecular partners; phytosterol; xenosterol; atherosclerosis; gall stone; ABC; transporter; ABC (ATP-binding cassette) transporters; multidrug resistance; transport; trafficking; urate; mutations; polymorphisms; ABCC6; TNAP; NT5E; Pseudoxanthoma elasticum (PXE); cancer; membrane protein; functional divergence; calcification; pseudoxanthoma elasticum; generalized arterial calcification of infancy; pyrophosphate; therapies; ABCA7; phagocytosis; Aβ peptides; yeast; multidrug transporter; anticancer; antifungal resistance; mechanism; peroxisome; adrenoleukodystrophy; fatty acids; gout; early-onset gout; hyperuricemia; uric acid; BCRP; single nucleotide polymorphism; SNP; homology modeling; substrate-binding site; cellular ATP efflux; mutagenesis; intracellular traffic; MDR3; phosphatidylcholine; RAB GTPase; taxol; drug transport; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one h...