The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria

• Weitere Verfasser: Broutin, Isabelle (Herausgegeben von), Vargiu, Attilio V (Herausgegeben von), Venter, Henrietta (Herausgegeben von), Phan, Gilles (Herausgegeben von)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Schlagworte: Research & information: general; Biology, life sciences; Microbiology (non-medical); MdtF (YhiV); multidrug resistance; RND-type efflux pump; dye accumulation; real-time efflux; pathogens; RND; evolution; efflux pump; adaptation; Aliarcobacter butzleri; RND efflux pumps; virulence; resistance; RND pump; dominant negative effect; assembly; protein-protein interaction; mutation; drug resistance; cystic fibrosis; prevalence of efflux resistance mechanisms; hospital acquired infections; antibiotic resistance; allostery; antimicrobial resistance; conformational changes; energetic transition; gram-negative bacteria; pump activation; n/a
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby...