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New Advances in Melanoma

Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metas...

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I tiakina i:
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Ētahi atu kaituhi: Larribère, Lionel (Editor)
Hōputu: Tāhiko Wāhanga pukapuka
Reo:Ingarihi
I whakaputaina: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Ngā marau:
Public health & preventive medicine
melanoma
targeted therapies
BRAF
druggable mutations
real-time PCR
NGS assay
immune escape
microRNA
transporter associated with antigen processing
incidence
population-based study
epidemiology
Spain
skin cancer
single-cell transcriptome sequencing
treatment response
pseudotime analysis
treatment
ubiquitination
miRNAs
embryogenesis
melanoblasts
melanoblast
NF1
transcriptome
RNAseq
Trp-1
metastasis
animal models
lung
mice
Urunga tuihono:DOAB: download the publication
DOAB: description of the publication
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Whakaahuatanga
Whakarāpopototanga:Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed.
Whakaahuatanga ōkiko:1 electronic resource (148 p.)
ISBN:books978-3-0365-3454-1
9783036534534
9783036534541
Urunga:Open Access

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