The Role of Extracellular Matrix in Cancer Development and Progression

• Other Authors: Tzanakakis, George (Editor), Nikitovic, Dragana (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; elastin; ribosomal protein SA; tongue carcinoma; MMP-2; EGCG; pancreatic ductal adenocarcinoma; syndecans; proteoglycans; tumor progression; angiogenesis; syndecan-4; heparan sulfate; cancer; prognosis; biomarker; signal transduction; proteoglycan; metastasis; extracellular matrix; fibrosis; immune cell modulation; neutrophils; neutrophil extracellular trap; macrophages; BCC; MMP; TIMP; invasion; lumican; cancer cell growth; motility; hyaluronan; RHAMM; CD44; wound repair; breast cancer; malignant pleural mesothelioma; pleural effusion; extracellular vesicles; biomarkers; sulfated hyaluronan; estrogen receptors; epithelial-to-mesenchymal transition; matrix metalloproteinases; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasa...