Molecular imaging in Parkinson's disease

The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychologi...

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Päätekijä: Polito, Cristina (auth)
Aineistotyyppi: Elektroninen Kirjan osa
Kieli:englanti
Julkaistu: Firenze Firenze University Press 2011
Sarja:Premio Tesi di Dottorato
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Yhteenveto:The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
Ulkoasu:1 electronic resource (68 p.)
ISBN:978-88-6655-041-9
9788866550419
9788866550372
9788892736450
Pääsy:Open Access