Phospholipases: From Structure to Biological Function

• Other Authors: Balboa, María A. (Editor), Balsinde, Jesús (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; inhibitor; metabolic stability; α-methylation; oxoesters; phospholipase A2; adrenic acid; arachidonic acid; mass spectrometry; lipid signaling; inflammation; monocytes/macrophages; crotoxin; snake venom; lung impairment; inflammatory response; lipid mediators; neuromuscular blocker; lipidomics; PAP-2; autotaxin; lysophosphatidate; G protein-coupled receptor; PLA2G6; fatty liver; phospholipid remodeling; diet-induced obesity; morbidly obesity; choline and methionine deficiency; glioblastoma; sphingolipid; sphingosine-1-phosphate; sphingomyelinase; sphingomyelin; metastasis; phosphatidic acid; diacylglycerol; lipin; signaling; cPLA2α; psoriasis; proliferation; anti-inflammatory; atherosclerosis; phospholipases; macrophages; T cells; lipins; pancreatic islets; β-cells; insulin secretion; glucose tolerance; insulin resistance; group VIA phospholipase A2; fatty acid; knockout mouse; lipid mediator; lysophospholipid; membrane; phospholipid; ceramide; acidic sphingomyelinase; neutral sphingomyelinase; hepatocellular carcinoma; alcoholic and nonalcoholic steatohepatitis; preadipocytes; prostaglandins; adipokines; cytokines; EP receptors; Group V phospholipase A2; lipids; majeed syndrome; LPIN2; LIPIN2; chronic non-bacterial osteomyelitis; chronic recurrent multifocal osteomyelitis; autoinflammatory; inflammasome; macrophage; osteoclast; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Phospholipases are a ubiquitous group of enzymes that hydrolyze ester bonds within membrane phospholipids. These enzymes serve multiple biological functions that go far beyond a mere membrane remodeling role in cellular homeostasis; they also play key functions in nutrient digestion and the regulate...