Mechanisms of ER Protein Import

• Other Authors: Zimmermann, Richard (Editor), Lang, Sven (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; chaperones; contact sites; endoplasmic reticulum; ER-SURF; membrane extraction; mitochondria; protein targeting; bimolecular luminescence complementation; competition; split luciferase; membrane proteins; protein-protein interactions; Sec61 complex; Sec63; synthetic peptide complementation; TRAP complex; ER protein translocase; signal peptide; protein translocation; nascent peptide chain; membrane insertion; molecular modelling; molecular dynamics simulations; molecular docking; signal peptidase; ER translocon; signal recognition particle dependent protein targeting; Sec61 dependent translocation; co-translational translocation; inhibitor; high throughput screening; Sec61; Sec62; folding; insertion; membrane protein; translocon; ribosome; transmembrane segment; lipid droplets; peroxisomes; PEX3; membrane protein insertion; label-free quantitative mass spectrometry; differential protein abundance analysis; Zellweger syndrome; GET; protein transport; SND; SRP; EMC; positive-inside rule; hydrophobicity; transmembrane helix; signal recognition particle; nascent polypeptide-associated complex; fidelity; cyclotriazadisulfonamide; ER quality control; DNAJC3; preprotein; Sec61 translocon; ribosome stalling; signal sequence; Sec61 translocase; NAC; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Protein import into the endoplasmic reticulum (ER) is the first step in the biogenesis of approximately 10,000 different soluble and membrane proteins of human cells, which amounts to about 30% of the proteome. Most of these proteins fulfill their functions either in the membrane or lumen of the ER...