Mitochondria-targeted drug delivery

• Other Authors: Kopecka, Joanna (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; retinal ischemia; blood-brain barrier; endothelial; reactive oxygen species; oxidative stress; tunneling nanotubules; neuron; central nervous system; inflammation; hypoxia; anticancer peptide (ACP); antimicrobial peptide (AMP); anticancer peptides; antimicrobial peptides; host defense peptides; prediction; random forest; mitochondria; mitochondrial DNA; mitochondrial disorders; pharmacological therapy; gene therapy; precision medicine; cardiovascular disease; drug delivery; mitochondria dysfunctions; nanocarriers; oxoglutarate carrier; malate-aspartate shuttle; cancer metabolism; ATP production; diphenyleneiodonium; NADPH-oxidase; differentiation; proliferation; mitochondria-targeted antioxidants; LPS; mitochondrial ROS; antitumor agents; fluorescence lifetime imaging; medicinal chemistry; metabolic drug; mitochondrial carrier; melanoma; plumbagin; cytotoxic effect; metabolism; cholesterol; lipid raft; mitochondrial permeability transition pore; alkylphospholipid analog; edelfosine; mitochondrial oncometabolites; cancer drug resistance; mitochondrial disease; heteroplasmy; mitochondrial gene delivery; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells' energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cel...