Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II

• Other Authors: Spetea, Mariana (Editor), van Rijn, Richard M. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Chemistry; thiazole; piperazine; tail-clip; hot-plate; acetic acid-induced writhing test; opioid; prodynorphin; epigenetics; transcription; human brain; morphine dosing; behavior; locomotor activity; tolerance; µ-opioid receptor; DAMGO; SR-17018; buprenorphine; nalbuphine; kappa opioid receptor agonist; pruritis; scratching; mice; TAT-HIV; cholestasis; chloroquine; deoxycholic acid; analgesic; δ opioid receptor; G-protein-biased agonist; opioid peptide; rubiscolins; µ-opioid analgesics; angiotensin receptors; chronic pain; neuropathic pain; delta opioid receptor; inverse agonist; irreversible antagonist; non-competitive antagonist; molecular pharmacology; free fatty acid receptors; lipids; opioid receptor; colitis; chemotype; high-throughput screen; allosteric modulation; beta-arrestin; molecular dynamics; opioid receptors; β-amino acids; peptide synthesis; receptor binding studies; functional assay; nociceptin/orphanin FQ receptor; NOP receptor; ligands; nociceptin; N/OFQ; analgesia; GPCR; HS-731; peripheral opioid agonist; binding; selectivity; molecular docking; molecular dynamics simulations; n/a; fluorescence cross-correlation spectroscopy (FCCS); G protein-coupled receptor (GPCR); serotonin
• Online Access: DOAB: download the publication; DOAB: description of the publication

Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modula...