Impaired Mitochondrial Bioenergetics under Pathological Conditions

• Other Authors: Lenaz, Giorgio (Editor), Nesci, Salvatore (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; Biochemistry; aging heart; Bcl-2 family; mitochondria; programmed cell death; fatty acid oxidation; palmitate; oleate; m.3243A> G mutation; MT-ATP6; m.8909T> C; ATP synthase; nephropathy; oxidative phosphorylation; mitochondrial disease; cardiolipin; Barth syndrome; Sengers syndrome; respiratory chain; Dilated Cardiomyopathy with Ataxia; cardiomyopathy; mammalian complex I; NADH dehydrogenase; complex I assembly; complex I structure; complex I deficiency; supernumerary subunits; electron transport chain; mitochondrial dysfunction; Leigh syndrome; mitochondrial diseases; yeast; Saccharomyces cerevisiae; pet mutants; pancreatic endocrine cells; mathematical model; cellular bioenergetics; diabetes; glucagon; insulin; exercise; immune system; metabolic disease; COVID-19; mitochondrial dynamics; viral infections; MAVS; RIG-I; MDA5; innate immune response; SARS CoV-2; RSV; influenza; respiratory supercomplexes; ROS; ATP synthase/hydrolase; mitochondrial permeability transition pore; cristae; cellular signaling; human disease; mitochondrial dynamic; cell signaling; cancer; respiratory complexes; oxidative stress; mitochondrial DNA; MTCYB mutations; cytochrome b; complex III; aging; energy metabolism; entorhinal cortex; lipoxidation-derived damage; neurodegeneration; oxidative damage; protein import; respiratory complex assembly; supercomplexes; mitochondrial proteostasis; heart failure; bioenergetics; assembly factor; atypical myopathy; high-resolution respirometry; toxicity assays; cell culture; equine primary myoblasts; fibroblasts; frozen tissue; leukocytes; oxygen consumption; platelets; respirometry; skeletal muscle; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the...