Brain-Targeted Drug Delivery

• Other Authors: Sousa, Flávia (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Technology: general issues; drug delivery into the brain; transendothelium based on receptor-mediated transcytosis; immunotherapy; Alzheimer's disease; anti-tau and anti-receptor bispecific monoclonal antibodies; Alzheimer's disease-relevant tau species; temporal-spatial pathological Aβ and tau distribution; interactions between Aβ and tau; tau clearance in microglia; tau clearance in neurons; liposome; nanoparticle; seizure; laser; ultrasound; naringenin; nanostructured lipid carrier; intranasal delivery; central composite rotatable design; depression; pomegranate seed oil; nasal delivery system; memory impairment; movement impairment; delivery to brain; improved memory; phospholipid oily gel; high-grade glioma; diffuse midline glioma; glioblastoma; IL-13Rα2; IL-13; immunotoxin; targeted therapy; GB-13; IL13.E13K-PE4E; receptor expression; acetaminophen; blood-brain barrier; claudin-5; CNS drug delivery; opioids; tight junction; microdialysis; cerebral open flow microperfusion; electrochemical biosensors; macromolecules; tolcapone; microparticles; nanoparticles; PLGA; Parkinson's disease; nose to brain delivery; gene therapy; polyplexes; hyaluronidase; glycol chitosan; brain cancer; chemoattractant; CXCL; CXCR; glioblastoma multiforme; 3D cell culture systems; non-human primate; convection-enhanced delivery; neurosurgery; optogenetics; brain targeted therapy; drug delivery; cerebrospinal fluid microcirculation; brain biodistribution; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer's and Parkinson's diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to...