Molecular Mechanism and Application of Somatic Cell Cloning in Mammals

• Other Authors: Samiec, Marcin (Editor), Skrzyszowska, Maria (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; cloned mammalian embryo; SCNT-derived progeny; mtDNA; nuclear-mitochondrial interaction; epigenetic reprogrammability; telomere shortening/attrition; domestic goat; somatic cell cloning; SCNT-derived embryo; genetically engineered specimen; gene targeting; genome editing; biopharmacy; biomedicine; nutri-biotechnology; genetically modified pig; epidermal keratinocyte; human α-1,2-fucosyltransferase; human α-galactosidase A; Galα1→3Gal epitope; pig; ovary; putative stem cells; nandrolone; boldenone; neoplastic transformation; cloned dog; brachygnathia inferior; whole-genome sequencing; Wnt signaling pathway; equine; dermal fibroblast cell; sarcoid; nucleofection; oncogenic/neoplastic transformation; RNA-Seq; NGS; transcriptome; oocyte; cumulus cells; 3D in vitro maturation; endocrine-active compounds; molecular quality; apoptotic cell death; mitochondria; mitophagy; domestic horse; dermal tissue; molecular pathway; ECM remodeling; cell adhesion; procancerous tumorigenesis; RNA-seq; swine; trichostatin A; epigenetic transformation; ex vivo model; tri-genetically modified; ACFC line; HLA-E; rhα-Gal A; rhα1,2-FT; α-Gal antigenic determinant; porcine skin xenograft; equine chondrocytes; 5-AZA-dc and TSA epigenetic modifiers; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic...