Molecular Mechanisms and Therapies of Colorectal Cancer

• Other Authors: Cave, Donatella Delle (Editor), Ottaiano, Alessandro (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Oncology; colorectal cancer; miRNA; ceRNA; lncRNA; circRNA; sponging; noninvasive biomarkers; MiR-199b; tumor suppressor; prognosis; LARC; HOX; HOXB9; colorectal liver metastases; metastatic colorectal cancer; structural variants; common fragile sites; platinum therapy; stalled replication fork; surgical oncology; liver regeneration; immunology; hepatic tissue-resident memory T cells; liver neoplasms; neoplasm metastasis; proteomics; biomarkers; mass spectrometry; microRNA; hypoxia; hypoxia-regulated microRNAs; fatty acid synthase; lipid metabolism; colorectal cancer initiation; Apc mutation; epigenetics; methylation; biomarker; S-Adenosylmethionine; breast cancer; Notch; metastasis; EMT; targeted sequencing; inflammatory bowel diseases; colitis-associated cancer; phosphatidylinositol 3-kinase; sortilin; neurotensin; neurotensin receptor-3; soluble sortilin; cell signaling; cell morphology; colorectal carcinoma; early onset CRC; multi-omics; lymphovascular invasion; perineural invasion; DNA damage repair; DNA replication repair; MMR; base excision repair; FASN; CTLA4; HAVCR2; TGF-β signaling; targeting therapy; immune-suppressive; barrier properties; colon; heterogeneity; cytokines; tumor necrosis factor alpha; interleukin 10; tight junction proteins; 1,2-dimethylhydrazine; rat; epithelial-to-mesenchymal transition; tumor-associated macrophages
• Online Access: DOAB: download the publication; DOAB: description of the publication

Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human de...