The Pathophysiology of Preeclampsia and Eclampsia

• Other Authors: Warrington, Junie P (Editor), Palei, Ana T. (Editor), Cunningham, Mark W. (Editor), Amaral, Lorena M. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; pre-eclampsia; eclampsia; pulmonary oedema; biobank; database; placental ischemia; seizure; ASIC2a; pregnancy; RUPP; pentylenetetrazol; melatonin; extracellular vesicle; exosome; preeclampsia; misfold proteins; endothelial cell activation; p21Cip1/CDKN1A; trophoblasts; hypoxia; trophoblast organoids; fusion; angiotensin II; AGTR1 (angiotensin II receptor type 1); bradykinin; BDKRB2 (bradykinin receptor B2); AT1R-B2R heteromer (protein complex formed of AT1R-B2R); G-protein-coupled receptor; protein aggregation; ARRB (beta-arrestin); early-onset preeclampsia; hemorheology; red blood cell aggregation; red blood cell deformability; erythrocyte; hypertension; IL-2; inflammation; oxidative stress; sFlt-1; NLRP3; nitric oxide; endothelial dysfunction; neuroinflammation; blood-brain barrier; cerebral edema; gestation; vessel; blood pressure; placenta; trophoblast; fetal growth restriction; maternal chronic venous disease (CVeD); anti-inflammation; antioxidant; ischaemia; vitamin E; glucose transporter 9; GLUT9; uric acid; cardiac dysfunction; placental factors; activin A; G-protein-coupled receptors; GPCR; weighted gene correlation network analysis; WGCNA; in vitro studies; cerebral biomarkers; NfL; tau; NSE; S100B; nebivolol; adrenoceptor; obesity; biomarkers; adipokines; adiponectin; leptin; ROS; angiogenic factors; hypoxia/reoxygenation; sFlT-1/PlGF ratio; primary trophoblast
• Online Access: DOAB: download the publication; DOAB: description of the publication

Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time t...