BRCA1 and BRCA2 Mutations Diagnostic and Therapeutic Implications
Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pa...
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Format: | Electronic Book Chapter |
Language: | English |
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IntechOpen
2023
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Online Access: | DOAB: download the publication DOAB: description of the publication |
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100 | 1 | |a Valarmathi, Mani T. |4 edt | |
700 | 1 | |a Valarmathi, Mani T. |4 oth | |
245 | 1 | 0 | |a BRCA1 and BRCA2 Mutations |b Diagnostic and Therapeutic Implications |
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520 | |a Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/3.0/ |2 cc |4 https://creativecommons.org/licenses/by/3.0/ | ||
546 | |a English | ||
650 | 7 | |a Medical genetics |2 bicssc | |
653 | |a Pre-clinical medicine: basic sciences | ||
856 | 4 | 0 | |a www.oapen.org |u https://mts.intechopen.com/storage/books/11593/authors_book/authors_book.pdf |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/97315 |7 0 |z DOAB: description of the publication |