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Pathogenesis and Targeted Therapy of Epilepsy

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Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respon...

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Bibliographic Details
Other Authors: N'Gouemo, Prosper (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:
Medicine
Neurosciences
3CAI
GRIA1
GRIA2
intractable epilepsy
PICK1
protein kinase C
pericytes
mural cells
cytokine
blood-brain barrier
neuroinflammation
3-phosphoinositide-dependent protein kinase-1
AKT
cyclosporin A
GluA1
GluR1
PDK1
refractory seizure
temporal lobe epilepsy
hippocampus
4-aminopyridine
epilepsy model
long-term potentiation
AMPA receptor
audiogenic epilepsy
rodents
fear reaction
behavior genetics
c-Fos
early gene activation
epileptogenesis
lipopolysaccharide
pentylenetetrazole
post-traumatic epilepsy
seizure susceptibility
traumatic brain injury
epilepsy
ghrelin
ghrelin receptor
anxiety
TRPV1 channels
neuronal activity
neuropsychiatric comorbidity
immunofluorescence
audiogenic kindling
acoustically evoked seizures
EACT
generalized tonic-clonic seizures
inherited epilepsy
TMEM1A channels
wild running seizures
astrocyte
ML365
pharmacoresistant epilepsy
cortical atrophy
hippocampal atrophy
intracerebral electrode
magnetic resonance imaging
posttraumatic epilepsy
n/a
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