Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma

• Other Authors: Szkandera, Joanna (Editor), Andreou, Dimosthenis (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Oncology; osteosarcoma; survival; prognosis; age groups; chemotherapy; metastasis; local recurrence; TEM1; VEGFR-1; EGFR; VEGFR-2; IGF-1R; PDGFRα; CD40; image guided surgery; near-infra red fluorescence; soft tissue sarcomas; angiosarcoma; paclitaxel; pazopanib; efficacy; toxicity; progression-free survival; sarcoma; radiotherapy; neoadjuvant therapy; hypofractionated radiotherapy; thermotherapy; hyperthermia; incisional biopsy; core needle biopsy; sensitivity; bone; soft tissue; LC3B; ATG16L1; p62; M6PR; PD-L1; CD8; notochord; tumor endoprosthesis; megaprosthesis; periprosthetic joint infection; revision surgery; bone sarcoma; extracellular acidosis; tumour microenvironment; tumour-associated stroma; acid-sensing ion channels; vacuolar-ATP-ase; carbonic anhydrase IX; acridine orange; soft tissue sarcoma; immune monitoring; immunophenotyping; cytokines; immune checkpoints; gene expression; Angiosarcoma; biomarkers; tumor microenvironment; immunotherapy; next-generation sequencing; whole transcriptome sequencing
• Online Access: DOAB: download the publication; DOAB: description of the publication

Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cyto...