Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

• Main Authors: Cassandre Labelle-Dumais (Author), Goutham Pyatla (Author), Seyyedhassan Paylakhi (Author), Nicholas G. Tolman (Author), Syed Hameed (Author), Yusef Seymens (Author), Eric Dang (Author), Anil K. Mandal (Author), Sirisha Senthil (Author), Rohit C. Khanna (Author), Meha Kabra (Author), Inderjeet Kaur (Author), Simon W. M. John (Author), Subhabrata Chakrabarti (Author), K. Saidas Nair (Author)
• Format: Book
• Published: The Company of Biologists, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from structural or functional alterations in ocular drainage tissu...