Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells
Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the HEK293 cell expression system. Cells were transfect...
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| Format: | Book |
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Elsevier,
2013-01-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yuki Ota |e author |
| 700 | 1 | 0 | |a Takuya Kawanai |e author |
| 700 | 1 | 0 | |a Ryo Watanabe |e author |
| 700 | 1 | 0 | |a Akira Nishimura |e author |
| 700 | 1 | 0 | |a Yukio Ago |e author |
| 700 | 1 | 0 | |a Kazuhiro Takuma |e author |
| 700 | 1 | 0 | |a Toshio Matsuda |e author |
| 245 | 0 | 0 | |a Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells |
| 260 | |b Elsevier, |c 2013-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.13012SC | ||
| 520 | |a Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the HEK293 cell expression system. Cells were transfected with the plasmid construct pcDNA3.1/V5-His containing full-length rat NCX1.5 cDNA. There was no difference in the cytotoxic effects of the NO donors sodium nitroprusside and S-nitroso-N-acetylpenicillamine between control and transfected cells. These results suggest that NO cytotoxicity is not dependent on NCX1.5. Keywords:: Na+/Ca2+ exchanger, nitric oxide, cytotoxicity | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 351-354 (2013) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319303664 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/000fdc93b7be4ddfa86a3707dd9d800f |z Connect to this object online. |