Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins

• Asıl Yazarlar: Dakshinamurthy Sivakumar (Yazar), Natarajan Hari (Yazar), Thirunavukkarasu Sivaraman (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Bangladesh Pharmacological Society, 2014-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We have herein computationally examined binding affinities and specificity of 2-hydroxy-3,5-dinitrobenzamide (HDNB), a small chemical molecular BH3-mimetic identified by means of peptidodynmimetic method, on the BH3-binding grooves of six anti-apoptotic proteins (Bcl-2, Bcl-B, Bcl-W, Bcl-XL, Bfl-1 a...