Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex

Oral multitarget tyrosine kinase inhibitors (TKIs), such as sorafenib, which suppress tumor cell proliferation and tumor angiogenesis, have been approved to treat patients with hepatocellular carcinoma (HCC). Of note, only approximately 30% of patients can benefit from TKIs, and this population usua...

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Main Authors: Li Gu (Author), Xin Jin (Author), Huaiyuan Liang (Author), Chong Yang (Author), Yu Zhang (Author)
Format: Book
Published: Elsevier, 2023-06-01T00:00:00Z.
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3rd Floor Main Library

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