Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

• Main Authors: Julia R. Varshavsky (Author), Swati D. G. Rayasam (Author), Jennifer B. Sass (Author), Daniel A. Axelrad (Author), Carl F. Cranor (Author), Dale Hattis (Author), Russ Hauser (Author), Patricia D. Koman (Author), Emily C. Marquez (Author), Rachel Morello-Frosch (Author), Catherine Oksas (Author), Sharyle Patton (Author), Joshua F. Robinson (Author), Sheela Sathyanarayana (Author), Peggy M. Shepard (Author), Tracey J. Woodruff (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence o...