Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss

• Päätekijät: Chong Cui (Tekijä), Daqi Wang (Tekijä), Bowei Huang (Tekijä), Fang Wang (Tekijä), Yuxin Chen (Tekijä), Jun Lv (Tekijä), Luping Zhang (Tekijä), Lei Han (Tekijä), Dong Liu (Tekijä), Zheng-Yi Chen (Tekijä), Geng-Lin Li (Tekijä), Huawei Li (Tekijä), Yilai Shu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2022-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools. However, it is difficult to precisely assess the editing performance in vivo because the tissues contain many non-targeted cells, which is one of the major barriers to clinical translation. Here, in the A...