Concepts for New Rapid Simple HPLC Method for Quantification of Fosfomycin Trometamol in Pharmaceutical Dosage Forms with Direct UV Detection

• Main Authors: Marjan Piponski (Author), Tanja Bakovska Stoimenova (Author), Tetiana Melnyk (Author), Sergiy Kovalenko (Author), Elena Lazarevska Todevska (Author), Marjan Velkovski (Author), Sami El Deeb (Author), Yuriy Mysula (Author), Liliya Logoyda (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two different concepts for developing direct HPLC-UV methods for quantifying fosfomycin trometamol were developed without any derivatization and modification of the analyte. In the first concept, without the use of alkylamines as ion-pairs in the mobile phase, by using cyanopropyl CN and a strong an...