Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

• Main Authors: Nienke Willemsen (Author), Isabel Arigoni (Author), Maja Studencka-Turski (Author), Elke Krüger (Author), Alexander Bartelt (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Regulation of proteasomal activity is an essential component of cellular proteostasis and function. This is evident in patients with mutations in proteasome subunits and associated regulators, who suffer from proteasome-associated autoinflammatory syndromes (PRAAS). These patients display...