Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing.

• Main Authors: Alex P Salam (Author), Alexandre Duvignaud (Author), Marie Jaspard (Author), Denis Malvy (Author), Miles Carroll (Author), Joel Tarning (Author), Piero L Olliaro (Author), Peter W Horby (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribavirin is currently the standard of care for treating Lassa fever. However, the human clinical trial data supporting its use suffer from several serious flaws that render the results and conclusions unreliable. We performed a systematic review of available pre-clinical data and human pharmacokine...