mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors

• Main Authors: Marie Millard (Author), Ilya Yakavets (Author), Max Piffoux (Author), Amanda Brun (Author), Florence Gazeau (Author), Jean-Michel Guigner (Author), Jordane Jasniewski (Author), Henri-Pierre Lassalle (Author), Claire Wilhelm (Author), Lina Bezdetnaya (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficient photodynamic therapy with meta-tetra(hydroxyphenyl)chlorine requires the application of specific nanoformulations. mTHPC liposomal formulation (Foslip®) demonstrated favorable pharmacokinetics properties. However, rapid liposomes destruction in circulation and rapid mTHPC release impedes F...