Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin

Anthrax toxin has evolved to translocate its toxic cargo proteins to the cytosol of cells carrying its cognate receptor. Cargo molecules need to unfold to penetrate the narrow pore formed by its membrane-spanning subunit, protective antigen (PA). Various alternative cargo molecules have previously b...

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Main Authors: Lukas Becker (Author), Jasleen Singh Badwal (Author), Fabian Brandl (Author), Wouter P. R. Verdurmen (Author), Andreas Plückthun (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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