Cytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime

• Main Authors: M. Mathy-Hartert (Author), G. Deby-Dupont (Author), C. Deby (Author), L. Jadoul (Author), A. Vandenberghe (Author), M. Lamy (Author)
• Format: Book
• Published: Hindawi Limited, 1995-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H2O2/Cl−). In this system, myeloperoxidase catalyses the conversion of H2O2 and CI− to the cytotoxic agent HOCl. Stimulated neutrophi...