Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

• Główni autorzy: Bridget L. Morse (Autor), Lisa Hong Chen (Autor), John T. Catlow (Autor), John K. Fallon (Autor), Philip C. Smith (Autor), Kathleen M. Hillgren (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased in vitro function correlate well with altered exposure of multiple OCT1 substrates in variant carriers. In t...