PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role

• Main Authors: Yinjiaozhi Li (Author), Ruoming Tan (Author), Ranran Li (Author), Rui Tian (Author), Zhaojun Liu (Author), Xiaoli Wang (Author), Erzhen Chen (Author), Tingting Pan (Author), Hongping Qu (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therapeutic targets. Glycolysis is critical to neutrophil activities during se...