Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization

• Main Authors: Maria B. C. de Matos (Author), Roel Deckers (Author), Benjamin van Elburg (Author), Guillaume Lajoinie (Author), Bárbara S. de Miranda (Author), Michel Versluis (Author), Raymond Schiffelers (Author), Robbert J. Kok (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells is one of the major risks in its clinical application, and we therefore propose to encapsulate ML1 in a nanocarrier that can specifically r...