Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats

• Main Authors: Kim Junghwan (Author), Lee Chang-Kwon (Author), Park Hyo-Jun (Author), Kim Hyo Jin (Author), So Hyun Ha (Author), Lee Keun Sang (Author), Lee Hwan Myung (Author), Roh Hui Yul (Author), Choi Wahn Soo (Author), Park Tae Kyu (Author), Kim Bokyung (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. EGF induced contraction...