Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats
Abstract.: We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. EGF induced contraction...
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| Main Authors: | , , , , , , , , , , |
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Elsevier,
2006-01-01T00:00:00Z.
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| 001 | doaj_0069a0299d6d4f36a9aa42e8e704cbf4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kim Junghwan |e author |
| 700 | 1 | 0 | |a Lee Chang-Kwon |e author |
| 700 | 1 | 0 | |a Park Hyo-Jun |e author |
| 700 | 1 | 0 | |a Kim Hyo Jin |e author |
| 700 | 1 | 0 | |a So Hyun Ha |e author |
| 700 | 1 | 0 | |a Lee Keun Sang |e author |
| 700 | 1 | 0 | |a Lee Hwan Myung |e author |
| 700 | 1 | 0 | |a Roh Hui Yul |e author |
| 700 | 1 | 0 | |a Choi Wahn Soo |e author |
| 700 | 1 | 0 | |a Park Tae Kyu |e author |
| 700 | 1 | 0 | |a Kim Bokyung |e author |
| 245 | 0 | 0 | |a Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats |
| 260 | |b Elsevier, |c 2006-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.FP0060021 | ||
| 520 | |a Abstract.: We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. EGF induced contraction and MAPK activity in aortic smooth muscle strips, which were significantly increased in tissues from the DOCA-salt hypertensive rats compared with those from sham-operated rats. AG1478, PD98059, and LY294002, inhibitors of EGF receptor (EGFR) tyrosine kinase, MAPK/extracellular signal-regulated kinase (ERK) kinase, and phosphatidylinositol 3-kinase (PI3K), respectively, inhibited the contraction and the activity of ERK1/2 that were elevated by EGF. Y27632 and GF109203X, inhibitors of Rho kinase and protein kinase C, respectively, attenuated EGF-induced contraction, with no diminution of ERK1/2 activity. Although EGF also elevated the activity of EGFR tyrosine kinase in both sham-operated and DOCA-salt hypertensive rats, the expression and the magnitude of activation did not differ between strips. These results strongly suggest that EGF induces contraction by the activation of ERK1/2, which is regulated by the PI3K pathway in the aortic smooth muscle of DOCA-salt hypertensive rats. Keywords:: epidermal growth factor, hypertension, vasoconstriction, mitogen-activated protein kinase, phosphatidylinositol 3-kinase | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 101, Iss 2, Pp 135-143 (2006) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319344585 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/0069a0299d6d4f36a9aa42e8e704cbf4 |z Connect to this object online. |