Modeling Chronic Toxicity: A Comparison of Experimental Variability With (Q)SAR/Read-Across Predictions

• Autors principals: Christoph Helma (Autor), David Vorgrimmler (Autor), Denis Gebele (Autor), Martin Gütlein (Autor), Barbara Engeli (Autor), Jürg Zarn (Autor), Benoit Schilter (Autor), Elena Lo Piparo (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

This study compares the accuracy of (Q)SAR/read-across predictions with the experimental variability of chronic lowest-observed-adverse-effect levels (LOAELs) from in vivo experiments. We could demonstrate that predictions of the lazy structure-activity relationships (lazar) algorithm within the app...