Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor

• Main Authors: Jiao Li (Author), Wei Zou (Author), Koukou Yu (Author), Bing Liu (Author), Weifeng Liang (Author), Lisha Wang (Author), Yin Lu (Author), Zequn Jiang (Author), Aiyun Wang (Author), Jiapeng Zhu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription. Inhibiting one or both of bromodomains resulted in different phenotypes, suggesting BD1 and BD2 may have different funct...