Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes

Protease-activated receptor 1 (PAR1) that can be activated by serine proteinases such as thrombin has been demonstrated to contribute to the development of cardiac remodeling and hypertrophy after myocardial injury. Here, we investigated the mechanisms by which PAR1 leads to hypertrophic cardiomyocy...

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Main Authors: Hitomi Otani (Author), Kei Yoshioka (Author), Hiroyuki Nishikawa (Author), Chiyoko Inagaki (Author), Tomoyuki Nakamura (Author)
Format: Book
Published: Elsevier, 2011-01-01T00:00:00Z.
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