Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

• Main Authors: Punyabhorn Rattanacheeworn (Author), Stephen J Kerr (Author), Wonngarm Kittanamongkolchai (Author), Natavudh Townamchai (Author), Suwasin Udomkarnjananun (Author), Kearkiat Praditpornsilpa (Author), Thanundorn Thanusuwannasak (Author), Udomsak Udomnilobol (Author), Suree Jianmongkol (Author), Boonsri Ongpipattanakul (Author), Thomayant Prueksaritanont (Author), Yingyos Avihingsanon (Author), Pajaree Chariyavilaskul (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ageing and chronic kidney disease (CKD) affect pharmacokinetic (PK) parameters. Since mechanisms are related and remain unclear, cytochrome P450 (CYP) 3A and drug transporter activities were investigated in the elderly with or without CKD and compared to healthy adults using a microdose...