Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity

• Main Authors: Nshunge Musheshe (Author), Asmaa Oun (Author), Angélica María Sabogal-Guáqueta (Author), Marina Trombetta-Lima (Author), Sarah C. Mitchel (Author), Ahmed Adzemovic (Author), Oliver Speek (Author), Francesca Morra (Author), Christina H. J. T. van der Veen (Author), Frank Lezoualc'h (Author), Xiaodong Cheng (Author), Martina Schmidt (Author), Amalia M. Dolga (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range of cellular functions including oxidative stress and cell survival. Mitochondrial-dependent oxidative stress has been associated with progressive neuronal death underlying the pathology of many neurodegenerat...