Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells

• 主要な著者: Daiane F. Engel (著者), Anna N. Grzyb (著者), Jade de Oliveira (著者), Alexandra Pötzsch (著者), Tara L. Walker (著者), Patricia S. Brocardo (著者), Gerd Kempermann (著者), Andreza F. de Bem (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2019-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked...