Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells

• Main Authors: Daiane F. Engel (Author), Anna N. Grzyb (Author), Jade de Oliveira (Author), Alexandra Pötzsch (Author), Tara L. Walker (Author), Patricia S. Brocardo (Author), Gerd Kempermann (Author), Andreza F. de Bem (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked...