Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

• Main Authors: Yu Zai (Author), Yuan Ying (Author), Zhuming Ye (Author), Mei Zhou (Author), Chengbang Ma (Author), Zhanzhong Shi (Author), Xiaoling Chen (Author), Xinping Xi (Author), Tianbao Chen (Author), Lei Wang (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DMPC-10A (ALWKKLLKK-Cha-NH₂) is a 10-mer peptide derivative from the N-terminal domain of Dermaseptin-PC which has shown broad-spectrum antimicrobial activity as well as a considerable hemolytic effect. In order to reduce hemolytic activity and improve stability to endogenous...