Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

• Egile Nagusiak: Yu Zai (Egilea), Yuan Ying (Egilea), Zhuming Ye (Egilea), Mei Zhou (Egilea), Chengbang Ma (Egilea), Zhanzhong Shi (Egilea), Xiaoling Chen (Egilea), Xinping Xi (Egilea), Tianbao Chen (Egilea), Lei Wang (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

DMPC-10A (ALWKKLLKK-Cha-NH₂) is a 10-mer peptide derivative from the N-terminal domain of Dermaseptin-PC which has shown broad-spectrum antimicrobial activity as well as a considerable hemolytic effect. In order to reduce hemolytic activity and improve stability to endogenous...