In silico modeling for ex vivo placenta perfusion of nicotine

• Ngā kaituhi matua: Harvey Ho (Author), Shengjie Zhang (Author), Ken Kurosawa (Author), Botao Jiang (Author), Koji Chiba (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Nicotine readily crosses the placenta to reach fetuses. However, membrane transporters, e.g., organic cation transporters (OCTs) play a role in the clearance of nicotine from the fetal to the maternal side, and this is rarely investigated clinically. In this work, we use an in silico model to simula...