In silico modeling for ex vivo placenta perfusion of nicotine

• Автори: Harvey Ho (Автор), Shengjie Zhang (Автор), Ken Kurosawa (Автор), Botao Jiang (Автор), Koji Chiba (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Nicotine readily crosses the placenta to reach fetuses. However, membrane transporters, e.g., organic cation transporters (OCTs) play a role in the clearance of nicotine from the fetal to the maternal side, and this is rarely investigated clinically. In this work, we use an in silico model to simula...