Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach

• Main Authors: Joanna Hajduk (Author), Cyrill Brunner (Author), Sebastian Malik (Author), Jana Bangerter (Author), Gisbert Schneider (Author), Marco Thomann (Author), Dietmar Reusch (Author), Renato Zenobi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotox...