Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation

• Những tác giả chính: Curtis C. Hughey (Tác giả), Freyja D. James (Tác giả), Zhizhang Wang (Tác giả), Mickael Goelzer (Tác giả), David H. Wasserman (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2019-05-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). Previous work showed endogenous glucose production is reduced in GNMT-null mice with gluconeogenic precursors being used in alternative biosynthetic pathways...