Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation

• Prif Awduron: Curtis C. Hughey (Awdur), Freyja D. James (Awdur), Zhizhang Wang (Awdur), Mickael Goelzer (Awdur), David H. Wasserman (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2019-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). Previous work showed endogenous glucose production is reduced in GNMT-null mice with gluconeogenic precursors being used in alternative biosynthetic pathways...