Development and Evaluation of Physiologically Based Pharmacokinetic Drug-Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

• Главные авторы: Muhammad F. Rasool (Автор), Sundus Khalid (Автор), Abdul Majeed (Автор), Hamid Saeed (Автор), Imran Imran (Автор), Mohamed Mohany (Автор), Salim S. Al-Rejaie (Автор), Faleh Alqahtani (Автор)
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• Опубликовано: MDPI AG, 2019-11-01T00:00:00Z.
• Предметы: article
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The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...