Development and Evaluation of Physiologically Based Pharmacokinetic Drug-Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

• 主要な著者: Muhammad F. Rasool (著者), Sundus Khalid (著者), Abdul Majeed (著者), Hamid Saeed (著者), Imran Imran (著者), Mohamed Mohany (著者), Salim S. Al-Rejaie (著者), Faleh Alqahtani (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2019-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...