Development and Evaluation of Physiologically Based Pharmacokinetic Drug-Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

• Main Authors: Muhammad F. Rasool (Author), Sundus Khalid (Author), Abdul Majeed (Author), Hamid Saeed (Author), Imran Imran (Author), Mohamed Mohany (Author), Salim S. Al-Rejaie (Author), Faleh Alqahtani (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...