ALDH1A2 (RALDH2) genetic variation in human congenital heart disease

• Main Authors: Mesquita Sonia MF (Author), Marques Lívia P (Author), Vasconcelos Michelle (Author), Cravo Roberta M (Author), Sobreira Tiago J (Author), Silva Fábio A (Author), Ruiz Viviane F (Author), Pavan Marilene (Author), Krieger José E (Author), Lopes Antônio AB (Author), Oliveira Paulo S (Author), Pereira Alexandre C (Author), Xavier-Neto José (Author)
• Format: Book
• Published: BMC, 2009-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Signaling by the vitamin A-derived morphogen retinoic acid (RA) is required at multiple steps of cardiac development. Since conversion of retinaldehyde to RA by retinaldehyde dehydrogenase type II (ALDH1A2, a.k.a RALDH2) is critical...