Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats

• Main Authors: Amira Awadalla (Author), Eman T. Hamam (Author), Fardous F. El-Senduny (Author), Nisreen Mansour Omar (Author), Mohamed R. Mahdi (Author), Nashwa Barakat (Author), Omar A. Ammar (Author), Abdelaziz M. Hussein (Author), Ahmed A. Shokeir (Author), Salma M. Khirallah (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To investigate the renoprotective, the antioxidant, and the anti-inflammatory impact of a combination of SPL and ZnO-NPs to combat against chronic kidney disease (CKD).Methods In total, 50 males of rats were distributed into 5 groups (10 rats each); normal group, adenine sulfate (0.25% in...