A Strong Impact of Genetic Background on Gut Microflora in Mice

• Main Authors: R. Steven Esworthy (Author), David D. Smith (Author), Fong-Fong Chu (Author)
• פורמט: ספר
• יצא לאור: Hindawi Limited, 2010-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Genetic background affects susceptibility to ileocolitis in mice deficient in two intracellular glutathione peroxidases, GPx1 and GPx2. The C57BL/6 (B6) GPx1/2 double-knockout (DKO) mice have mild ileocolitis, and 129S1/Sv (129) DKO mice have severe inflammation. We used diet to modulate ileocolitis...